This never happened.  Unlike some of his less fortunate followers, Muhammad enjoyed the protection of his powerful uncle, Abu Talib:

[The leading men of Mecca] went to Abu Tablib [and said] “Your nephew has cursed our gods, insulted our religion, mocked our way of life and accused our forefathers of error. Either you must stop him or you must let us get at him”

The apostle continued on his way… In consequence, his relations with the Quraish [Meccans] deteriorated and men withdrew from him in enmity. (Ibn Ishaq/Hisham 168).

For thirteen years, the worst that ever happened to Muhammad at Mecca was that he had dust thrown on him by a heckler and was occasionally mocked while praying at the Kaaba.  He continued to provoke the Meccans, at one point telling them that he had come to bring them "slaughter."  This caused them to seize Muhammad in an attempt (by one named Uqba) to "throttle" him, but he was released unharmed almost immediately:

Then they left him. That is the worst that I ever saw the Quraish do to him. (Ibn Ishaq/Hisham 184).

I asked 'Abdullah bin 'Amr bin Al-'As to inform me of the worst thing the pagans had done to Allah's Apostle. He said: "While Allah's Apostle was praying in the courtyard of the ka'ba, 'Uqba bin Abi Mu'ait came and seized Allah's Apostle by the shoulder and twisted his garment round his neck and throttled him severely. Abu Bakr came and seized 'Uqba's shoulder and threw him away from Allah's Apostle and said, "Would you kill a man because he says: 'My Lord is Allah,' and has come to you with clear Signs from your Lord?" (Bukhari 60:339)

Though not injured, Muhammad would have his opportunity to forgive the man who had seized him when Uqba was captured following the Battle of Badr.  According to his biographers, the prophet of Islam chose instead to have him slaughtered even as the unarmed prisoner begged for his life.

The Hadith also confirms that Muhammad was not physically harmed by the Meccans:

Allah's Apostle said, "Doesn't it astonish you how Allah protects me from the Quraish's abusing and cursing?  They abuse Mudhammam and curse Mudhammam while I am Muhammad (and not Mudhammam)" (Bukhari 56:733)

Neither does the Qur'an provide any support for the contemporary thesis that Muhammad suffered physical abuse at Mecca, despite the many harsh things said about those who rejected him - the redundancy of which is so abundant in the Qur'an that it comprises the majority of the text.